CP110 (CCP110) (NM 014711) Humaan Recombinant eiwit

Necessary for centrosome duplication at different stages of procentriole formation. Acts as a key negative regulator of ciliogenesis in collaboration with CEP97 by capping the mother centriole thereby preventing cilia formation (PubMed:17719545 PubMed:17681131, PubMed:23486064) . Also involved in promoting ciliogenesis. May play a role in the assembly of the mother centriole subdistal appendages (SDA) thereby effecting the fusion of recycling endosomes to basal bodies during cilia formation (By similarity) . Required for correct spindle formation and has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CETN2 (PubMed:16760425) .[UniProtKB/Swiss-Prot Function]

Purified recombinant protein of Human CP110 protein (CP110), transcript variant 2, Asp291-Lys404, with N-terminal His tag, expressed in E. coli, 50ug

Cep110; CP110

9738

O43303

NM_014711

16p12.3

E. coli

N-His

>50 ug/mL as determined by microplate BCA method

> 80% as determined by SDS-PAGE and Coomassie blue staining

Liquid

25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1% Sarkosyl.

12.3 kDa

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

CCP110

Human

NP_055526

https://www.ncbi.nlm.nih.gov/gene/9738

https://www.uniprot.org/uniprot/O43303

https://www.ncbi.nlm.nih.gov/nuccore/NM_014711

https://www.ncbi.nlm.nih.gov/nuccore/NP_055526