CPI-455
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
CPI-455 (1628208-23-0) is a potent (IC50 = 10 nM) and selective inhibitor of the lysine demethylase KDM5 (equal inhibition of KDM5A, 5B, 5C) .1 CPI-455 reduced the number of drug-tolerant persister cancer cells (DTPs) in a dose-dependent, KDM5-dependent manner in multiple cell lines treated with standard chemotherapy or targeted agents. CPI-455 synergized with 5-aza-2’-deoxycytidine (DAC) to reduce the viability of luminal breast cancer cells in vitro.2 KDM5 demethylases have recently been shown to repress the immune response to tumors via suppression of STING.3
Unconjugated
Off-white solid
-20°C
Beschrijving
CPI-455 Beschikbaar in 5 mg. Bestel eenvoudig online met snelle levering.
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