CRB1 Antilichaam

CRB1 Antibody: CRB1 (Crumbs homolog 1) plays a role in photoreceptor morphogenesis in the retina. It may maintain cell polarization and adhesion. CRB1 is similar to the Drosophila crumbs protein and localizes to the inner segment of mammalian photoreceptors. The first identified human homolog, CRB1, is expressed in retina and some parts of the brain, leaving room for another homolog to function in epithelial tissues. Mutations in this gene are associated with a severe form of retinitis pigmentosa, RP12, and with Leber congenital amaurosis.

23418

P82279

NP_001180569

Human

Unconjugated

Primary Antibodies

Signal Transduction

CRB1 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1308 - Human Small Intestine Tissue Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Mouse: (82%)

CRB1 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

CRB1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

Predicted: 142 kDa

IgG

Alternatively spliced transcript variants have been observed. CRB1 antibody i spredicted to not cross-react with CRB2.

CRB1

Crumbs homolog 1 (Drosophila)

Homo sapiens

Van de Pavert SA, Kantardzhieva A, Malysheva A, et al. Crumbs homologue 1 is required for maintenance of photoreceptor cell polarization and adhesion during light exposure. J. Cell Sci. 2004; 117:4169-77.

Van de Pavert SA, Sanz AS, Aartsen WM, et al. Crb1 is a determinant of retinal apical Muller glia cell features. Glia 2007; 55:1486-97.

Den Hollander AI, Johnson K, de Kok YJ, et al. CRB1 has a cytoplasmic domain that is functionally conserved between human and Drosophila. Hum. Mol. Genet. 2001; 10:2767-73.

Bujakowska K, Audo I, Mohand-Said S, et al. CRB1 mutations in inherited retinal dystrophies. Hum. Mutat. 2012; 33:306-15.

CRB1 Antibody: LCA8, RP12, Protein crumbs homolog 1

ELISA, WB

302370926

Liquid