CRB2 Antilichaam

CRB2 Antibody: CRB2 (Crumbs homolog 2), like its homologs CRB1 and CRB3, is similar to the Drosophila crumbs protein and is expressed in retina, brain and kidney. Along with other proteins, the Crumbs proteins form a complex that help set up cell polarity in developing neuroepithelial cells. At the onset of neural specification, embryonic stem cells (ESCs) upregulate CRB2, which then localizes apically in neural rosettes. Gain- and loss-of-function studies of CRB2 have shown that CRB2 is essential for the stabilization of other polarity proteins. Unlike CRB1, mutations in CRB2 do not appear to play a role in retinitis pigmentosa or in Leber congenital amaurosis.

286204

Q5IJ48

NP_775960

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Stem Cell

CRB2 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1463 - Rat Brain Tissue Lysate

1 mg/mL

CRB2 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

CRB2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

At least three isoforms of CRB2 are known to exist; this antibody will detect all three. CRB2 antibody is predicted to not cross-react with other members of the CRB family.

CRB2

Cat. No. 1305 - Human Kidney Tissue Lysate

Cat. No. 1403 - Mouse Brain Tissue Lysate

Crumbs homolog 2 (Drosophila)

Homo sapiens

Van den Hurk J, Rashbass P, Roepman R, et al. Characterization of the Crumbs homolog 2 (CRB2) gene and analysis of its role in retinits pigmentosa and Leber congenital amaurosis. Mol. Viso. 2005; 11:263-73

Bulgakova NA and Knust E. The Crumbs complex: from epithelial-cell polarity to retinal degeneration. J. Cell Sci. 2009; 122:2587-96.

Boroviak T and Rashbass P. The apical polarity determinant Crumbs 2 is a novel regulator of ESC-derived neural progenitors. Stem Cells 2011; 29:193-205

Bujakowska K, Audo I, Mohand-Said S, et al. CRB1 mutations in inherited retinal dystrophies. Hum. Mutat. 2012; 33:306-15

CRB2 Antibody: Protein crumbs homolog 2, Crumbs-like protein 2

ELISA, WB

112420992

Liquid