CRBN ligand-187
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
CRBN ligand-187 is a CRBN-type E3 ubiquitin ligase ligand that can be used for synthesis of TQ-3959.
2883704-28-5
12352005
H302-H315-H319-H335
Ligands for E3 Ligase
PROTAC
Cancer
NC1=CC2=C(C=C1)C(C3CCC(NC3=O)=O)=NO2
C12H11N3O3
245.23
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
[1]Ren J, et al. Discovery of TQ-3959 as a Potent and Orally Bioavailable BTK PROTAC Degrader Incorporating a Novel Benzisoxazole-Based CRBN Ligand for the Treatment of B-Cell Malignancies. J Med Chem. 2025 Aug 14;68 (15) :15960-15979.
Room temperature
http://file.medchemexpress.com/batch_PDF/HY-W733888/
Reference compound1
No Development Reported
Beschrijving
CRBN ligand-187 is a CRBN-type E3 ubiquitin ligase ligand that can be used for synthesis of TQ-3959.
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