CREBL1 Antilichaam - middengebied: FITC (ARP31562 P050-FITC)

Activating transcription factor 6 beta

G13, CREBL1, CREB-RP

1388

Q99941

NP_004372

Human, Mouse, Rat, Cow, Dog, Horse, Pig

The immunogen is a synthetic peptide directed towards the middle region of human CREBL1

ATF6B (CREBL1) is a transcription factor in the unfolded protein response (UPR) pathway during ER stress. Either as a homodimer or as a heterodimer with ATF6-alpha, the protein binds to the ER stress response element, interacting with nuclear transcription factor Y to activate UPR target genes. ATF6B is normally found in the membrane of the endoplasmic reticulum; however, under ER stress, the N-terminal cytoplasmic domain is cleaved from the rest of the protein and translocates to the nucleus. Two transcript variants encoding different isoforms have been found for this gene.The protein encoded by this gene bears sequence similarity with the Creb/ATF subfamily of the bZip superfamily of transcription factors. It localizes to both the cytoplasm and the nucleus. The gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

CREBZF; XBP1; ATF6B; CDK6; UBC; SUMO2; ATF6; NFYC; MBTPS1; PHOX2A; MBTPS2; NFYA; HCVgp1

FITC: Fluorescein Isothiocyanate

Polyclonal Antibody

WB

Affinity Purified

0.5 mg/ml

Cow: 86%; Dog: 93%; Horse: 93%; Human: 100%; Mouse: 86%; Pig: 85%; Rat: 86%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

77kDa

Xie, T., (2003) Genome Res. 13 (12), 2621-2636

Wet Ice

703

ATF6B

ATF6B

Rabbit

Cyclic AMP-dependent transcription factor ATF-6 beta

NM_004381

FNRTESLRLADELSGWVQRHQRGRRKIPQRAQERQKSQPRKKSPPVKAVP