Crenolanib
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
Crenolanib is a potent inhibitor of PDGFR (Kd for α = 2.1 nM; ß = 3.2 nM) and FLT3 (Kd = 0.74 nM) .1 Crenolanib is a type I inhibitor binding only to the active kinase conformation. It showed potent activity against imatinib-resistant PDGFRα mutations D842I, D842V, D842Y, DI842-843M, and deletion I8432 as well as FLT3/ITD and FLT3/D835 mutants3. Crenolanib acted synergistically with FLT3-CAR T-cells in a FLT3-ITD+ AML murine xenograft model.4
Unconjugated
White solid
-20°C
Beschrijving
Crenolanib Beschikbaar in 5 mg. Bestel eenvoudig online met snelle levering.
Specificaties
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