CRH-antilichaam

Corticotropin-releasing hormone (CRH) is secreted by the paraventricular nucleus (PVN) of the hypothalamus in response to stress (1) . In addition to production in the hypothalamus, this protein is also synthesized in peripheral tissues, such as T lymphocytes and is highly expressed in the placenta where it is a marker that determines the length of gestation and the timing of parturition and delivery. A rapid increase in circulating levels of the hormone occurs at the onset of parturition, suggesting that, in addition to its metabolic functions, this protein may act as a trigger for parturitio (2) . Marked reduction in this protein has been observed in association with Alzheimer disease (3) .

1392

P06850

NP_000747

Human

Unconjugated

Primary Antibodies

Homeostasis, Neuroscience

CRH antibody is affinity chromatography purified via peptide column.

Cat. No. 1309 - Human Placenta Tissue Lysate

1 mg/mL

CRH antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

CRH antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

CRH antibody is human specific.

CRH

Cat. No. 10-301 - Human Brain Tissue Slide

Corticotropin releasing hormone

Homo sapiens

Maras PM and Baram TZ. Sculpting the hippocampus from within: stress, spines, and CRH. Trends Neurosci. 2012; 315-24.

Vrachnis N, Malamas FM, Sifakis S, et al. Immune aspects and myometrial actions of progesterone and CRH in labor. Clin. Dev. Immunol. 2012; 937618.

Leake A, Perry EK, Perry RH, et al. Neocortical concentrations of neuropeptides in senile dementia of the Alzheimer and Lewy body type: comparison with Parkinson's disease and severity correlations. Biol. Psychiatry 1991; 29:357-64.

CRH Antibody: CRF, Corticoliberin, Corticotropin-releasing factor, CRF

ELISA, WB, IHC-P, IF

4503041

Liquid