CrkRS Antilichaam / CDK12 / Cycline-afhankelijke kinase 12

CrkRS, also known as Cdc2-related kinase, arginine/serine-rich, CDK12 and Cyclin-dependent kinase 12, is a cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. It also regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability.

Western blot: 1:500-1:1000

Q9NYV4

Human, Mouse

A portion of amino acids 1-30 from the human protein was used as the immunogen for this CrkRS antibody.

WB

Purified

This CrkRS antibody is available for research use only.

Aliquot the CrkRS antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

In 1X PBS, pH 7.4, with 0.09% sodium azide

Titration of the CrkRS antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Western blot testing of mouse liver tissue lysate with CrkRS antibody. Predicted molecular weight ~164 kDa.