CRSP6 Antilichaam - N-terminaal gebied: Biotine (ARP34192_P050-Biotine)

Mediator complex subunit 17

SRB4, CRSP6, CRSP77, DRIP80, TRAP80

9440

Q9NVC6

NP_004259

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit

The immunogen is a synthetic peptide directed towards the N terminal region of human CRSP6

The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by CRSP6 is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor- (TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors.

UBC; BRCA1; CDK19; CDK8; MED26; POLR2C; ESR2; MED19; FBXW7; EPAS1; TFIP11; MED24; MED21; MED14; MED11; MED28; WDR33; CPSF2; UBD; BCL6; SMARCA4; SUZ12; MED10; CTDP1; SREBF1; MED25; MED15; TRA; MED1; OBFC1; MED18; ZC3H13; MED12; QKI; TRIP4; TADA2A; SUPT7L

Biotin

Polyclonal Antibody

IHC, WB, CHIP

Affinity Purified

MED17 is supported by BioGPS gene expression data to be expressed in HepG2

0.5 mg/ml

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 92%; Rabbit: 100%; Rat: 100%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

73kDa

Wang, Q., et al., (2002) J. Biol. Chem. 277 (45), 42852-42858

Wet Ice

651

MED17

MED17

Rabbit

Mediator of RNA polymerase II transcription subunit 17

NM_004268

AAQILLKGAERLTKSVTENQENKLQRDFNSELLRLRQHWKLRKVGDKILG

17