CRTC2 Antilichaam

CRTC2 Antibody: CRTC2, also known as TORC2 (Transducers Of Regulated cAMP Response Element-Binding (CREB) ) 2 and the related protein CRTC1 are potent CREB coactivators that are exported from the nucleus in a CRM1-dependent manner via phosphorylation-dependent interactions. Studies suggest that their phosphorylation and nuclear/cytoplasmic shuttling play an important role in the regulation of gluconeogenesis by cAMP. CRTC2 is present in both B and T-lymphocytes and abundantly expressed in the thymus. Its activity is important in regulating the expression of genes involved in cellular energy metabolism while CRTC1 is essential for energy balance and fertility.

200186

Q53ET0

NP_859066

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Signal Transduction

CRTC2 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1308 - Human Small Intestine Tissue Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Bovine: (94%)

CRTC2 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

CRTC2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

Multiple isoforms of CRTC2 are known to exist. CRTC2 antibody is predicted to not cross-react with CRTC1.

CRTC2

Cat. No. 11-801 - Human Small Intestine Tissue Slide

CREB regulated transcription coactivator 2

Homo sapiens

Conkright MD, Canettieri G, Screaton R, et al. TORCs: transducers of regulated CREB activity. Mol. Cell 2003; 12:413-23.

Iourgenko V, Zhang W, Mickanin C, et al. Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells. Proc. Natl. Acad. Sci. USA 2003; 100:12147-52.

Bittinger MA, McWhinnie E, Meltzer J, et al. Activation of cAMP response element-mediated gene expression by regulated nuclear transport of TORC proteins. Curr. Biol. 2004; 14: 2156-61.

Jiang S, Inada T, Tanaka M, et al. Involvement of TORC2, a CREB co-activator, in the in vivo-specific transcriptional control of HTLV-1. Retrovirology 2009; 6:73.

CRTC2 Antibody: TORC2, TORC-2, TORC2, CREB-regulated transcription coactivator 2, Transducer of regulated cAMP response element-binding protein 2

ELISA, WB, IHC-P, IF

32171215

Liquid