CRYAB Antibody - C-terminal regio : FITC (ARP48196_T100-FITC)

Crystallin, alpha B

MFM2, CRYA2, CTPP2, HSPB5, CMD1II, CTRCT16, HEL-S-101

1410

P02511

EAW67166

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Sheep

The immunogen is a synthetic peptide directed towards the C terminal region of human CRYAB

Alpha crystallins are composed of: alpha-A and alpha-B, for acidic and basic, respectively. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone; instead they hold them in large soluble aggregates. Post-translational modifications decrease the ability to chaperone. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. Alpha-A and alpha-B are differentially expressed; alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Elevated expression of alpha-B crystallin occurs in many neurological diseases; a missense mutation cosegregated in a family with a desmin-related myopathy.

CRYAB; CRYAA; KRTAP19-5; KRTAP8-1; TRAPPC6A; MRPL11; TNPO2; ACOT7; HSPB1; CASP7; CASP3; CASP2; PIDD1; DDX20; CRADD; B2M; APOC2; XIAP; CASP12; SOD1; HSPB2; HBA1; CASP9; CASP8; CASP6; ASB5; SMAD4; TRIM33; UBC; CCL22; CTNNB1; CRYGD; CDH1; SNCA; GFAP; FGF2; F

FITC: Fluorescein Isothiocyanate

Polyclonal Antibody

WB

0.5 mg/ml

Cow: 93%; Dog: 93%; Guinea Pig: 93%; Horse: 93%; Human: 100%; Mouse: 100%; Rabbit: 86%; Rat: 100%; Sheep: 92%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

20kDa

Wet Ice

175

CRYAB

CRYAB

Rabbit

Alpha-crystallin B chain

NM_001885

KYRIPADVDPLTITSSLSSDGVLTVNGPRKQVSGPERTIPITREEKPAVT