Cryptophycine 52

Cryptophycin 52 (LY355703) is a synthesized 16-membered cyclic ester peptide compound and is a derivative of marine natural product cryptophycin 1. Cryptophycin 52 shows inhibitory activity against various tumor cells with an IC50 of 24.8 pmol/L for HL-60 cells. Cryptophycin 52 can induce cells G2/M phase arrest. Cryptophycin 52 is also effective for solid tumors that are resistant to Paclitaxel and Doxorubicin (HY-15142A). Cryptophycin 52 can be used for the research of cancer, such as multidrug-resistant tumor[1].

186256-67-7

LY355703

12352005

Drug Derivative

Others

Cancer

C[C@@H]([C@@]1([H])OC([C@@H](OC(C(C)(CNC([C@H](NC(/C=C/C1)=O)CC2=CC(Cl)=C(C=C2)OC)=O)C)=O)CC(C)C)=O)[C@]3([H])[C@@H](C4=CC=CC=C4)O3

C36H45ClN2O8

669.20

[1]Al-Awar RS, et al. Biological evaluation of cryptophycin 52 fragment A analogues: effect of the multidrug resistance ATP binding cassette transporters on antitumor activity. Mol Cancer Ther. 2004 Sep;3 (9) :1061-7.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-180942/

Reference compound

No Development Reported