CS-VIP 8
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
CS-VIP 8 is a selective allosteric WDR5 protein inhibitor (Ki= 0.008 μM) . CS-VIP 8 induces conformational changes in the MLL1 complex, leading to the dissociation of MLL1 from the complex, inhibiting MLL1 histone methyltransferase activity and regulating HOX gene expression. CS-VIP 8 is promising for research of hematological diseases such as leukemia[1].
12352209
Histone Methyltransferase; WDR5
Epigenetics
Neuroscience-Neuromodulation
Cardiovascular Disease
O=C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC)C(N[C@H](CC1=CC=CC=C1)C2=O)=O)=O)[C@H](NC(C(C)C)=O)CCNC(C(C=C3F)=CC(F)=C3N=NC4=C(F)C=C(C(NCCN2)=O)C=C4F)=O
C43H52F4N12O7
924.94
[1]Albert L, et al. Bistable Photoswitch Allows in Vivo Control of Hematopoiesis. ACS Cent Sci. 2022 Jan 26;8 (1) :57-66.
Room temperature
http://file.medchemexpress.com/batch_PDF/HY-P10948/
Peptides
No Development Reported
Beschrijving
CS-VIP 8 is a selective allosteric WDR5 protein inhibitor (Ki= 0.008 μM) . CS-VIP 8 induces conformational changes in the MLL1 complex, leading to the dissociat
Specificaties
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