CS-VIP 8 (hydrochloride)

CS-VIP 8 hydrochloride is a selective allosteric WDR5 protein inhibitor (Ki= 0.008 μM) . CS-VIP 8 hydrochloride induces conformational changes in the MLL1 complex, leading to the dissociation of MLL1 from the complex, inhibiting MLL1 histone methyltransferase activity and regulating HOX gene expression. CS-VIP 8 hydrochloride is promising for research of hematological diseases such as leukemia[1].

12352209

Histone Methyltransferase; WDR5

Epigenetics

Neuroscience-Neuromodulation

Cardiovascular Disease

96.04

DMSO : 10 mg/mL (ultrasonic; warming; heat to 60°C)

O=C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC)C(N[C@H](CC1=CC=CC=C1)C2=O)=O)=O)[C@H](NC(C(C)C)=O)CCNC(C(C=C3F)=CC(F)=C3N=NC4=C(F)C=C(C(NCCN2)=O)C=C4F)=O.Cl

C43H53ClF4N12O7

961.40

[1]Albert L, et al. Bistable Photoswitch Allows in Vivo Control of Hematopoiesis. ACS Cent Sci. 2022 Jan 26;8 (1) :57-66.

Blue Ice

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

http://file.medchemexpress.com/batch_PDF/HY-P10948A/CS-VIP-8-hydrochloride-SDS-MedChemExpress.pdf

Peptides

No Development Reported