CSNK1E Antibody - N-terminal regio : FITC (ARP51987_P050-FITC)

Casein kinase 1, epsilon

CKIe, HCKIE, CKIepsilon

1454

P49674

NP_001885

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Sheep, Yeast, Zebrafish

The immunogen is a synthetic peptide directed towards the N terminal region of human CSNK1E

Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. CSNK1E can phosphorylate a large number of proteins. CSNK1E participates in Wnt signaling and is the central component of the circadian clock. It may act as a negative regulator of circadian rhythmicity by phosphorylating PER1 and PER2. CSNK1E inhibits cytokine-induced granuloytic differentiation.The protein encoded by this gene is a serine/threonine protein kinase and a member of the casein kinase I protein family, whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein is found in the cytoplasm as a monomer and can phosphorylate a variety of proteins, including itself. This protein has been shown to phosphorylate period, a circadian rhythm protein. Two transcript variants encoding the same protein have been found for this gene.

DVL3; TIAM1; UBC; REST; ZSWIM8; TAZ; SAV1; DVL2; ADAM22; SNX24; AHCYL2; PER1; MCC; HMMR; TCEB2; STK3; SEC13; CSNK1D; CSNK1A1; CRY1; ACACA; FAM83H; FAM83B; VPS13B; FAM199X; KLHDC3; FAM110B; FAM110A; FAM83D; C2orf44; SNX22; STOX2; UNC45A; PPP6R3; WDR5; SDCC

FITC: Fluorescein Isothiocyanate

Polyclonal Antibody

WB

Affinity Purified

0.5 mg/ml

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Sheep: 100%; Yeast: 93%; Zebrafish: 93%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

47kDa

Levran, O., (er) Genes Brain Behav. (2008) In press

Wet Ice

416

CSNK1E

CSNK1E

Rabbit

Casein kinase I isoform epsilon

NM_001894

MELRVGNKYRLGRKIGSGSFGDIYLGANIASGEEVAIKLECVKTKHPQLH