CST3 Antilichaam

The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes the most abundant extracellular inhibitor of cysteine proteases, which is found in high concentrations in biological fluids and is expressed in virtually all organs of the body. A mutation in this gene has been associated with amyloid angiopathy. Expression of this protein in vascular wall smooth muscle cells is severely reduced in both atherosclerotic and aneurysmal aortic lesions, establishing its role in vascular disease. In addition, this protein has been shown to have an antimicrobial function, inhibiting the replication of herpes simplex virus. Alternative splicing results in multiple transcript variants encoding a single protein.

1471

P01034

Human, Mouse

Recombinant fusion protein containing a sequence corresponding to amino acids 27-146 of human CST3 (NP_000090.1) .

Unconjugated

Primary Antibodies

Apoptosis, Cell Cycle, Neuroscience, Stem Cell

Affinity purification

U-251MG

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 15kDa

IgG

CST3

SKOV3

A-549

Mouse brain

Cystatin C

Homo sapiens

CST3, cystatin C, ARMD11, MGC117328, OTTHUMP00000030440, OTTHUMP00000164181, OTTHUMP00000164182, bA218C14.4 (cystatin C), cystatin 3, cystatin C (amyloid angiopathy and cerebral hemorrhage), gamma-trace, neuroendocrine basic polypeptide, post-gamma-globulin

WB, IHC, IF

Liquid