CT-08

CT-08 (CT8, Compound 3) is a macrocyclic Sec61 modulator, blocks protein secretion in a signal sequence-dependent manner. CT-08 blocks Sec61-mediated translocation of VCAMss-GLuc into the ER, resulting in a loss of luciferase activity. CT-08 inhibits VCAM expression in transfected cells[1][2].

1000770-96-6

12352209

Others

Others

Cancer-programmed cell death

Cancer

O=C(N[C@H](C(N([C@H](C(O[C@@H](C(N[C@H](C(N([C@H](C(N[C@H](C(N1C)=O)CC(C)C)=O)CC(C)C)C)=O)C[C@H](C)CCCC)=O)CC#C)=O)C)C)=O)C[C@H](C)CCCC)[C@@H]1CC2=CC=CC=C2

C50H80N6O8

893.21

[1]Dustin Mcminn, et al. Preparation of thiazole carboxamides as protein secretion inhibitors for treatment of cancer and inflammation. WO2019046668A1. 2019-03-07. |[2]MacKinnon AL, et al. Photo-leucine incorporation reveals the target of a cyclodepsipeptide inhibitor of cotranslational translocation. J Am Chem Soc. 2007 Nov 28;129 (47) :14560-1.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-P10477/

Peptides

No Development Reported