CTHRC1 Antilichaam

The Collagen triple helix repeat-containing protein (CTHRC1) is a glycosylated, secreted protein that is transiently expressed in the arterial wall in response to injury where it is thought to contribute to vascular remodeling by inhibiting collagen expression and deposition and promoting cell migration (1) . CTHRC1 is highly expressed multiple human cancers, including pancreatic cancer where it plays a significant role in the progression and metastasis of the disease by regulating migration and adhesion of tumors cells (2) . CTHRC1 overexpression can also be used as an independent prognostic marker in gastric cancer (3) . Mutations at this locus have been associated with Barrett esophagus and esophageal adenocarcinoma (4) .

115908

Q96CG8

NP_612464

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Cancer

CTHRC1 antibody is affinity chromatography purified via peptide column.

Cat. No. 1468 - Rat Small Intestine Tissue Lysate

1 mg/mL

CTHRC1 antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

CTHRC1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

CTHRC1 antibody is human, mouse and rat reactive. At least two isoforms of CTHRC1 are known to exist; this antibody will detect only the larger isoform.

CTHRC1

Cat. No. 11-801 - Human Small Intestine Tissue Slide

Collagen triple helix repeat-containing protein 1

Homo sapiens

Pyagay P, Heroult M, Wang Q, et al. Collagen triple helix repeat containing 1, a novel secreted protein in injured and diseased arteries, inhibits collagen expression and promotes cell migration. Circ. Res. 2005; 96:261-8.

Park EH, Kim S, Jo JY, et al. Collagen triple helix repeat containing-1 promotes pancreatic cancer progression by regulating migration and adhesion of tumor cells. Carcinogenesis 2013; 34:694-702.

Gu L, Liu L, Zhong L, et al. Cthrc1 overexpresion is an independent prognostic marker in gastric cancer. Hum. Pathol. 2014; 45:1031-8.

Orloff M, Peterson C, He X, et al. Germline mutations in MSR1, ASCC1, and CTHRC1 in patients with Barrett esophagus and esophageal adenocarcinoma. JAMA 2011; 306:410-9.

Collagen triple helix repeat-containing protein 1

ELISA, WB, IHC-P, IF

19923989

Liquid