CTLA-4 (CD152) Recombinant eiwit, humaan
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
The human CTLA-4 is a recombinant protein consists of a single glycosylated polypeptide chain with 149 amino acids (36-161aa) . CTLA-4 (CD152) is the first identified co-inhibitory molecule and clinically targeted immune checkpoint receptor, expressed on T cells where it primarily downregulates early T cell activation. CTLA-4 counteracts CD28 activity, a T cell co-stimulatory receptor, by binding to CD80 (B7-1) and CD86 (B7-2) with higher affinity. By outcompeting CD28 for these ligands, CTLA-4 diminishes T cell activation and delivers inhibitory signals, playing crucial roles in both innate and adaptive immune responses. Abbreviations: IDDM12, CELIAC3, GSE, CTLA-4, CD152.
The human CTLA-4 is a recombinant protein consists of a single glycosylated polypeptide chain with 149 amino acids (36-161aa) . CTLA-4 (CD152) is the first identified co-inhibitory molecule and clinically targeted immune...
CTLA-4 (CD152) Recombinant Protein, Human, 25ug
25μg / vial
Cell Signaling Pathways
> 95%, as determined by SDS-PAGE
Soluble
15.9kDa
Stable at 4°C for one month or stored in the dark at -20°C long-term.
E. coli
Beschrijving
The human CTLA-4 is a recombinant protein consists of a single glycosylated polypeptide chain with 149 amino acids (36-161aa) . CTLA-4 (CD152) is the first iden
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