CTLA4 / CD152 Proteïne (rFc-tag)

Cytotoxic T-lymphocyte protein 4, also known as CTLA4 and CD152, is a single-pass type I membrane protein and a member of the immunoglobulin superfamily. It is the second member of the CD28 receptor family. The ligands or counterreceptors for these two proteins are the B7 family members, CD80 (B7-1) and CD86 (B7-2) . CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T cells and may play an important role in their functions. CD152 or cytotoxic T lymphocyte antigen-4 (CTLA-4) is an essential receptor involved in the negative regulation of T cell activation. Because of its profound inhibitory role, CD152 has been considered a sound susceptible candidate in autoimmunity and a persuasive target for cancer immunotherapy. In particular, recent evidence suggests that CD152 is also important in the homeostasis and function of a population of suppressive cells, termed regulatory T cells (Treg) .

ALPS5 Protein; CD Protein; CD152 Protein; CELIAC3 Protein; CTLA-4 Protein; GRD4 Protein; GSE Protein; IDDM12 Protein

NP_005205.2

Human

Human

RFc-Tag

See Datasheet send with the product

< 1.0 EU per μg of the protein as determined by the LAL method

> 90 % as determined by SDS-PAGE.

Immobilized Anti-CTLA4 (BMS) Antibody, Human IgG1 at 2 μg/mL (100 μL/well) can bind Recombinant Human CTLA4 / CD152 Protein (rFc Tag), the EC50 is 0.8-2.4 ng/mL.

358

Lyophilized

PBS, pH 7.4

See Datasheet

39.7 kDa

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

HEK 293 cells