CTnI Antilichaam [3A10A12]

CTnI has an apparent molecular weight of 22.5 kDa. cTnI is a candidate marker with acceptable sensitivity and specificity for AMI and other cardiac diseases. Troponin, a molecule that binds to the thin filament (actin) of striated muscle fibers, acts with intracellular calcium to control the interaction of the thin filament with the thick filament (myosin), thus regulating muscle contraction. Troponin I prevents muscle contraction in the absence of calcium, which has two skeletal muscle isoforms with considerable amino acid sequence homology. cTnI contains an additional N-terminal sequence and is highly specific for myocardium.

7137

P19429

P19429

Human

Ni-NTA purified truncated recombinant cTnI expressed in E. Coli strain BL21 (DE3) .

3A10A12

Unconjugated

Primary Antibodies

Other

Batch dependent

Ascitic fluid containing 0.03% sodium azide.

None

Blue Ice

CTnI monoclonal antibody can be stored at -20˚ C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG1

TNNI3

Troponin I type 3 (cardiac)

Homo sapiens

Cummins B and Cummins P, J Mol Cell Cardiol, 1987, 19 (10) :999-1010.

Cummins B, Auckland ML, and Cummins P, Am Heart J, 1987, 113 (6) :1333-44.

Darnell J, Lodish H, and Baltimore D, Molecular Cell Biology, New York, NY: Scientific American Books, 1986, 827-8.

Larue C, Defacque-Lacquemant H, Calzolari C, et al, Mol Immunol, 1992, 29 (2) :271-8.

TNNC1, Cardiac troponin ICMH7, RCM1, cTnI, CMD2A, TNNC1, CMD1FF

ELISA, WB, IHC

136213