CTTNBL1 Antilichaam

CTTNBL1 Antibody: The Beta-catenin-like protein 1 (CTNNBL1) contains an acidic domain, a putative bipartite nuclear localization signal, a nuclear export signal, a leucine-isoleucine zipper, and phosphorylation motifs, as well as Armadillo/beta-catenin-like repeats. Transient expression of CTNNBL1 resulted in translocation to the nucleus and apoptosis, suggesting it may be involved in the apoptotic pathway. CTNNBL1 interacts with the Prp19 complex of the spliceosome and the Ig class switching enzyme activation-induced deaminase (AID) and had been suggested to play a role in antibody-diversification and class switching, but recent studies have shown CTNNBL1 to be dispensable for Ig class switch recombination. Other studies have identified CTTNBL1 as a novel gene for obesity.

56259

Q8WYA6

NP_110517

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Apoptosis

CTTNBL1 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1303 - Human Brain Tissue Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Bovine: (95%)

CTTNBL1 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

CTTNBL1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

CTNNBL1 antibody is predicted to not cross-react with other catenin family members. At least four isoforms of CTNNBL1 are known to exist; this antibody will detect all but isoform b.

CTNNBL1

Catenin, beta like 1

Homo sapiens

Jabbour L, Welter JF, Kollar, et al. Sequence, gene structure, and expression pattern of CTNNBL1, a minor-class intron-containing gene - evidence for a role in apoptosis. Genomics 2003; 81:292-303.

Conticello SG, Ganesh K, Xhu K, et al. Interaction between antibody-diversification enzyme AID and spliceosome-associated factor CTNNBL1. Mol. Cell 2008; 31:474-84.

Han L, Masani S, and Yu K. Cutting edge: CTNNBL1 is dispensable for Ig class switch recombination. J. Immunol. 2010; 185:1379-81.

Liu YJ, Liu XG, Wang L, et al. Genome-wide association scans identified CTNNBL1 as a novel gene for obesity. Hum. Mol. Genet. 2008; 17:1803-13.

CTTNBL1 Antibody: NAP, P14L, PP8304, C20orf33, dJ633O20.1, Beta-catenin-like protein 1, Nuclear-associated protein, NAP

ELISA, WB, IHC-P, IF

18644734

Liquid