CV-6504

CV-6504 is a dual inhibitor of TXA2 synthase and 5-lipoxygenase. CV-6504 can scavenge ROS and exhibit antitumor activity. CV-6504 can be used for the researches of cancer, inflammation and cardiovascular disease[1][2].

117574-40-0

12352005

H302-H315-H319-H335

Lipoxygenase; Prostaglandin Receptor

GPCR/G Protein; Metabolic Enzyme/Protease

Cancer; Inflammation/Immunology; Cardiovascular Disease

O=C1C(C)=C(C)C(C(C)=C1CC2=CC=CN=C2)=O

C15H15NO2

241.29

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

[1]Terao S, et al. Synthesis and biological evaluation of 2,3,5-trimethyl-6- (3-pyridylmethyl) -1,4-benzoquinone (CV-6504), a dual inhibitor of TXA2 synthase and 5-lipoxygenase with scavenging activity of active oxygen species (AOS) . Adv Prostaglandin Thromboxane Leukot Res. 1991;21A:173-6.|[2]Hussey HJ, et al. Mechanism of the anti-tumour effect of 2,3,5-trimethyl-6- (3-pyridylmethyl) 1,4-benzoquinone (CV-6504) . Br J Cancer. 1997;75 (6) :845-9.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-19064/

Reference compound2

Phase 2

5-LOX; TXA2/TP