CX-5461
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
CX-5461 (1138549-36-6) is a first-in-class selective RNA polymerase I inhibitor, suppressing Pol I transcription in MV 4;11 myelomonocytic leukemia cells and SR immunoblastic lymphoma cells with EC50 values of 95 and 135 nM respectively and demonstrating 200-fold selectivity over Pol II.1,2 Activates the DNA damage response.3 It induces a rapid accumulation of cytosolic DNA which results in upregulation of STING.4 Acts as a potent immunosuppressant inhibiting T cell-mediated alloimmunity and representing a novel class of immunosuppressant.5
Unconjugated
Off-white solid
RT
Beschrijving
CX-5461 Beschikbaar in 5 mg. Bestel eenvoudig online met snelle levering.
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