CX3CR1 Antilichaam

CX3CR1 Antibody: CX3CR1 is one of the chemokine receptors that are required as coreceptors for HIV infection. The genes encoding human, murine, and rat CX3CR1 were cloned and designated V28 and CMKBRL1, CX3CR1, and RBS11, respectively. The encoded seven transmembrane protein was recently identified as the receptor for a novel transmembrane molecule, fractalkine, and renamed CX3CR1. Recently, CX3CR1 was found to serve as a coreceptor for HIV-1 and HIV-2 envelope fusion and virus infection, which can be inhibited by fractokine. CX3CR1 mediates leukocyte migration and adhesion. CX3CR1 is expressed in a variety of human tissues and cell lines.

1524

P49238

NP_001328

Human, Mouse, Rat

2093

Unconjugated

Primary Antibodies

KD Validation (Figure 2) : Anti-CX3CR1 antibody (2093) specificity was further verified by CX3CR1 specific knockdown. CX3CR1 signal in 293 cells transfected with CX3CR1 siRNAs was disrupted in comparison with that in cells transfected with control siRNAs. KD Validation (2093) Regulated expression validation (Figure 13) : CX3CR1 expression detected by anit-CX3CR1 antibodies (2093) was up-regulated by IL-2, which was inhibited by IL-15. Regulated expression validation2093 Deficiency Validation (Figure 15) : CX3CR1+ cells detected by anti-CX3CR1 antibodies is localized in vascular wall of CX3CR1+/gfp mice, but not in CX3CR1gfp/gfp mice, where cells remained in perivascular region. Deficiency Validation+/gfpgfp/gfp

Chemokines & Cytokines, Cancer, Infectious Disease

CX3CR1 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1306 - Human Spleen Tissue Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Bovine: (82%)

CX3CR1 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

CX3CR1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

Human CX3CR1 has 3 isoforms, including isoform 1 (355aa, 40kD), isoform 2 (387aa, 44kD), isoform 3 (362aa, 41kD) . Mouse CX3CR1 has one isoform (354aa, 40kD) and rat CX3CR1 also has one isoform (354aa, 40kD) . 2093 can detect all isoforms of human, mouse and rat.

CX3CR1

Cat. No. 10-501 - Human Heart Tissue Slide

Cat. No. 1466 - Rat Spleen Tissue Lysate

Cat. No. 1208 - THP-1 Cell Lysate

Chemokine (C-X3-C motif) receptor 1

Homo sapiens

Raport et al. Gene 1995;163:295-9.

Combadiere et al. DNA Cell Biol 1995;14:673-80.

Combadiere et al. Biochem Biophys Res Commun 1998;253:728-32.

Harrison et al. Neurosci Lett 1994;169:85-9.

14581400

12881312

15934075

23437346

23324824

26684242

22198947

18285406

17962485

19327232

27789999

CX3CR1 Antibody: V28, CCRL1, GPR13, CMKDR1, GPRV28, CMKBRL1, CX3C chemokine receptor 1, Beta chemokine receptor-like 1, C-X3-C CKR-1

ELISA, WB, IHC-P, IF, Flow

4503171

Liquid