CXCR3 Antilichaam

The CXCR3 protein is a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine induced by interferon-gamma), CXCL10/IP10 (interferon-gamma-inducible 10 kDa protein) and CXCL11/I-TAC (interferon-inducible T cell alpha-chemoattractant) (reviewed in 1) . Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration (2) . Similar to other chemokine receptors such as CXCR4, CXCR3 has been implicated in several malignancies as a biomarker of tumor behavior as well as a potential therapeutic target (3) .

2833

P49682

NP_001136269

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Chemokines & Cytokines

CXCR3 antibody is affinity chromatography purified via peptide column.

Cat. No. 1211 - HepG2 Cell Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Goat: (89%), Bovine: (88%)

CXCR3 antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

CXCR3 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

CXCR3 antibody is human, mouse and rat reactive. At least two isoforms of CXCR3 are known to exist; this antibody will detect both isoforms.

CXCR3

Cat. No. 17-011 - Hep G2 Cell Slide

Chemokine (C-X-C motif) receptor 3

Homo sapiens

Groom JR and Luster AD. CXCR3 ligands: redundant, collaborative and antagonistic functions. Immunol. Cell Biol. 2011; 89:207-15.

Maghazachi AA. Role of chemokines in the biology of natural killer cells. Curr. Top Microbiol. Immunol. 2010; 341:37-58.

Fulton AM. The chemokine receptors CXCR4 and CXCR3 in cancer. Curr. Oncol. Rep. 2009; 11:125-31.

CXCR3 Antibody: GPR9, MigR, CD182, CD183, Mig-R, CKR-L2, CMKAR3, IP10-R, GPR9, C-X-C chemokine receptor type 3, CXC-R3

ELISA, WB, ICC, IF

218563730

Liquid