CXCR4-Lo Antilichaam

CXCR4-Lo Antibody: Human immunodeficiency virus (HIV) and related viruses require coreceptors, in addition to CD4, to infect target cells. Some G protein-coupled receptors including CCR5, CXCR4, CCR3, CCR2b and CCR8 in the chemokine receptor family, and four new human molecules GPR15, STRL33, GPR1 and V28 were recently identified as HIV coreceptors. Among them, CXCR4 is a principal coreceptor for T-cell tropic strains of HIV-1 fusion and entry of human white blood cells. CXCR4 is also required for the infection by dual-tropic strains of HIV-1 and mediates CD-4 independent infection by HIV-2. The alpha-chemokine SDF-1 is the ligand for CXCR4 and prevents infection by T-tropic HIV-1. CXCR4 associates with the surface CD4-gp120 complex before HIV enters target cells. CXCR4 messenger RNA levels correlated with HIV-1 permissiveness in diverse human cell types. Antibodies to CXCR4 block HIV-1 and HIV-2 fusion and infection of human target cells. The amino-terminal domain and the second extracellular loop of CXCR4 serve as HIV binding sites.

7852

P61073

NP_001008540

Human

Unconjugated

Primary Antibodies

Infectious Disease

CXCR4-Lo Antibody is affinity chromatography purified via peptide column.

Cat. No. 1306 - Human Spleen Tissue Lysate

1 mg/mL

CXCR4-Lo Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

CXCR4-Lo antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

This antibody is specific for the longer isoform of CXCR4.

CXCR4

Cat. No. 17-001 - HeLa Cell Slide

Chemokine (C-X-C motif) receptor 4

Homo sapiens

Dimitrov DS. Cell1997; 91:721-30.

Feng Y et al. Science1996; 272:872-7.

Berson JF et al. J. Virol.1996; 70:6288-95.

Doranz BJ et al. Cell 1996; 85:1149-58.

CXCR4-Lo Antibody: FB22, HM89, LAP3, LCR1, NPYR, WHIM, CD184, LESTR, NPY3R, NPYRL, HSY3RR, NPYY3R, D2S201E, C-X-C chemokine receptor type 4, FB22, CXC-R4

ELISA, WB, ICC, IF

56790927

Liquid