CXL-017

CXL 017 is a sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) inhibitor. CXL 017 can inhibit the ATPase activity of SERCA by competing with ATP for binding. CXL 017 exhibits selective cytotoxicity against multidrug-resistant acute myeloid leukemia cells HL60/MX2. CXL 017 can be used in the research of tumors such as multidrug-resistant acute myeloid leukemia[1].

1063714-11-3

12352005

Calcium Channel

Membrane Transporter/Ion Channel; Neuronal Signaling

Cancer-programmed cell death

Cancer

O=C(C1=C(N)OC2=C(C=C(C3=CC(OC)=CC(OC)=C3)C=C2)C1CC(OCC)=O)OCC

C24H27NO7

441.47

[1]Bleeker NP, et al. A novel SERCA inhibitor demonstrates synergy with classic SERCA inhibitors and targets multidrug-resistant AML. Mol Pharm. 2013 Nov 4;10 (11) :4358-66.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-18051/

Reference compound1

No Development Reported