Cy5-Paclitaxel (bromide)

Cy5-Paclitaxel bromide is the bromide of Cy5-Paclitaxel. Cy5-Paclitaxel is a Cyanine5 carboxylic acid bromide (HY-D1319) labeled Paclitaxel (HY-B0015) conjugate. Cyanine5 carboxylic acid bromide is a fluorescent dye containing a non-activated carboxylic acid (Ex=646 nm, Em=662 nm) that can be used for molecular labeling and microscopy imaging. Paclitaxel stabilizes tubulin polymerization. Paclitaxel can cause both mitotic arrest and apoptotic cell death. Paclitaxel also induces autophagy[1].

12352005

Autophagy; Fluorescent Dye; Microtubule/Tubulin

Autophagy; Cell Cycle/DNA Damage; Cytoskeleton; Others

Cancer

O=C(CCCCC[N+]1=C(/C=C/C=C/C=C2C(C)(C)C(C=CC=C3)=C3N\2C)C(C)(C)C4=C1C=CC=C4)O[C@@H](C(O[C@H]5C[C@@]([C@H]([C@]([C@](C([C@@H]6OC(C)=O)=O)([C@H]7O)C)([H])[C@]8([C@@H](C7)OC8)OC(C)=O)OC(C9=CC=CC=C9)=O)(C(C)(C6=C5C)C)O)=O)[C@@H](NC(C%10=CC=CC=C%10)=O)C%11=CC=CC=C%11.[Br-]

C79H88BrN3O15

1399.46

[1]Xu C, et al. Photo-controlled release of paclitaxel and model drugs from RNA pyramids. Nano Res. 2019 Jan;12 (1) :41-48.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-D2422C/

Dye Reagents

No Development Reported