Cyanostatine B

Cyanostatin B, a cyanobacterial lipopeptide, is a leucine aminopeptidase M (LAP) inhibitor (IC50 = 12 ng/mL) . Cyanostatin B is a weak inhibitor of protein phosphatase (PP2A) and also exhibits weak inhibitory activity against angiotensin-converting enzyme (ACE), with an IC50 value of 130 μg/mL. Cyanostatin B demonstrates both cytotoxic and genotoxic effects on human hepatocytes, although non-toxic to Artemia salina. Cyanostatin B inhibits the proliferation of HepG2 cells, induces DNA single-strand breaks, and causes genomic instability.[1][2].

850131-23-6

12352209

Aminopeptidase; Angiotensin-converting Enzyme (ACE) ; DNA/RNA Synthesis; Phosphatase

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Cancer

OC(C=C1)=CC=C1C[C@H](NC([C@@H](O)[C@H](N)CCCCCCC)=O)C(N(C)[C@@H]([C@@H](C)CC)C(N2[C@@H](CCC2)C(N[C@H](C(O)=O)CC3=CC=C(C=C3)O)=O)=O)=O

C40H59N5O9

753.92

[1]Ujvárosi AZ, et al. The cyanobacterial oligopeptides microginins induce DNA damage in the human hepatocellular carcinoma (HepG2) cell line. Chemosphere. 2020 Feb;240:124880. |[2]Sano T, et al. Leucine aminopeptidase M inhibitors, cyanostatin A and B, isolated from cyanobacterial water blooms in Scotland. Phytochemistry. 2005 Mar;66 (5) :543-8.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-P11334/

Peptides

No Development Reported