Cycline D1 (fosfo Ser90) Antilichaam

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and auto-ubiquitination of STUB1, TRAF6 and TRIM63/MURF1. Ubiquitinates STUB1-associated HSP90AB1 in vitro. Lacks inherent specificity for any particular lysine residue of ubiquitin. Essential for viral activation of IRF3. Mediates polyubiquitination of CYP3A4.

595

P24385

NP_444284.1

Human, Mouse, Rat

Cyclin D1 (phospho Ser90) antibody was raised against a peptide sequence around phosphorylation site of serine 90 (F-L-S (p) -L-E) derived from Human Cyclin D1 .

Unconjugated

Primary Antibodies

Phospho-Specific

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Phospho-Specific

Blue Ice

Store antibody at -20˚ C for up to one year.

31 kDa

IgG

The antibody detects endogenous level of Cyclin D1 only when phosphorylated at serine 90.

Western Blot: 1:500~1:1000

CCND1

Cyclin D1

Homo sapiens

Sewing A, Müller R (1994) Oncogene 9, 2733-6

BCL1, CCND1, CYL-1, PRAD1, PRAD1 oncogene

WB

116152

Liquid