Cycline E1 (fosfo Thr395) Antilichaam

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition.

898

P24864

NP_001229.1

Human

Cyclin E1 (phospho-Thr395) antibody was raised against a peptide sequence around phosphorylation site of threonine 395 (L-L-T (p) -P-P) derived from Human Cyclin E1.

Unconjugated

Primary Antibodies

Phospho-Specific, Cell Cycle

Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Phospho-Specific

Blue Ice

Store antibody at -20˚ C for up to one year.

48 kDa

This antibody detects endogenous level of Cyclin E1 only when phosphorylated at threonine 395.

Western Blot: 1:1000

CCNE1

Cyclin E1

Homo sapiens

Won K. A., Reed S. I. EMBO J. 15:4182-4193 (1996) Welcker M., Singer J., Loeb K. R., Grim J., Bloecher A., Mol. Cell 12:381-392 (2003)

CCNE, SIGLEC2, CCNE, CCNE1

WB

17318559

Liquid