Cycline H (fosfo Thr315) Antilichaam

Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.

902

P51946

NP_001230.1

Human, Mouse

Cyclin H (phospho Thr315) antibody was raised against a peptide sequence around phosphorylation site of threonine 315 (E-W-T (p) -D-D) derived from Human Cyclin H .

Unconjugated

Primary Antibodies

Phospho-Specific

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Phospho-Specific

Blue Ice

Store antibody at -20˚ C for up to one year.

36 kDa

IgG

The antibody detects endogenous levels of Cyclin H only when phosphorylated at threonine 315.

Western Blot: 1:500~1:1000

CCNH

Cyclin H

Homo sapiens

Maekelae T.P., Nature 371:254-257 (1994) .

Fisher R.P., Cell 78:713-724 (1994) .

The MGC Project Team; Genome Res. 14:2121-2127 (2004) .

Cyclin H, p34, p37, MO15-associated protein

WB

4502623

Liquid