Cycline O Antilichaam

Cyclin O Antibody: Cyclin O, also known as CCNO, has recently been identified as a Cdk1- and Cdk2-activating cyclin specific to apoptosis in lymphoid cells. Cyclin O binds to and activates Cdk2 in response to instrinsic apoptotic stimuli such as glucocorticoids or DNA-damaging agents. Supression of Cyclin O expression by shRNA leads to the inhibition of glucocorticoid and DNA-damage-induced apoptosis due to a failure of apical caspase activation while leaving the CD95 death receptor-mediated apoptosis intact. Note: this gene, which had a previous symbol of UNG2, was erroneously identified as a uracil DNA glycosylase. A later publication identified this gene's product as a cyclin protein family member.

10309

P22674

NP_066970

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Apoptosis

Cyclin O Antibody is affinity chromatography purified via peptide column.

Cat. No. 1310 - Human Bladder Tissue Lysate

1 mg/mL

Cyclin O Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

Cyclin O antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

39 kDa

IgG

At least two isoforms of Cyclin O are known to exist; this antibody will recognize both isoforms.

CCNO

Cyclin O

Homo sapiens

Roig MB, Roset R, Ortet L, et al. Identification of a novel cyclin required for the intrinsic apoptosis pathway in lymphoid cells. Cell Death Diff. 2009; 16:230-43.

Muller SJ and Caradonna S. Isolation and characterization of a human cDNA encoding uracil-DNA glycosylase. Biochim. Biophys. Acta 1991; 1088:197-207.

Muller SJ and Caradonna S. Cell cycle regulation of a human cyclin-like gene encoding uracil-DNA glycosylase. J. Biol. Chem. 1993; 268:1310-9.

Cyclin O Antibody: CCNU, UDG2, Cyclin-O

ELISA, WB

153791755

Liquid