Cyclische ADP-ribose (diammonium)

Cyclic ADP-ribose diammonium (cADPR diammonium) is a potent second messenger for calcium mobilization that is synthesized from NAD+ by an ADP-ribosyl cyclase. Cyclic ADP-ribose diammonium increases cytosolic calcium mainly by Ryanodine receptor-mediated release from endoplasmic reticulum and also by extracellular influx through the opening of TRPM2 channels[1][2][3][4][5].

CADPR (diammonium)

12352005

Calcium Channel; Endogenous Metabolite; TRP Channel

Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling

COVID-19-immunoregulation

Infection; Inflammation/Immunology; Neurological Disease

O[C@H]1[C@@H](O)[C@H](N(C=N2)C3=C2C(N(C=N3)[C@@H]([C@H](O)[C@@H]4O)O[C@@H]4CO5)=N)O[C@@H]1COP(OP5(O)=O)(O)=O.N.N

C15H27N7O13P2

575.36

[1]Galione A, et, al. Ca (2+) -induced Ca2+ release in sea urchin egg homogenates: modulation by cyclic ADP-ribose. Science. 1991 Sep 6;253 (5024) :1143-6.|[2]Lee HC, et, al. Structural determination of a cyclic metabolite of NAD+ with intracellular Ca2+-mobilizing activity. J Biol Chem. 1989 Jan 25;264 (3) :1608-15.|[3]Ribeiro JM, et, al. Specific cyclic ADP-ribose phosphohydrolase obtained by mutagenic engineering of Mn 2+-dependent ADP-ribose/CDP-alcohol diphosphatase. Sci Rep. 2018 Jan 18;8 (1) :1036.|[4]Verderio C, et, al. Evidence of a role for cyclic ADP-ribose in calcium signalling and neurotransmitter release in cultured astrocytes. J Neurochem. 2001 Aug;78 (3) :646-57.|[5]Zhong J, et, al. Cyclic ADP-Ribose and Heat Regulate Oxytocin Release via CD38 and TRPM2 in the Hypothalamus during Social or Psychological Stress in Mice. Front Neurosci. 2016 Jul 22;10:304.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-N7395B/

Natural Products

No Development Reported