Cyclo (L-leucyl-L-tryptofyl)

Cyclo (L-leucyl-L-tryptophyl) (Cyclo (-Leu-Trp) ) is a cyclic dipeptide that inhibits a various of bacteria and fungi. Cyclo (L-leucyl-L-tryptophyl) is a melatonin receptor agonist and is also used as a bitter ligand[1][2][3].

15136-34-2

Cyclo (Leu-Trp)

12352209

Bacterial; Fungal; Melatonin Receptor

Anti-infection; GPCR/G Protein; Neuronal Signaling

COVID-19-immunoregulation

Infection; Neurological Disease

99.90

O=C(N[C@H](C(N1)=O)CC(C)C)[C@@H]1CC2=CNC3=CC=CC=C23

C17H21N3O2

299.37

[1]Shiba T, et al. Some aspects of the relationship between the structure of a bitter diketopiperazine and its receptor. Biopolymers. 1981 Sep;20 (9) :1985-7. |[2]Kumar SN, et al. Purification, structural elucidation and bioactivity of tryptophan containing diketopiperazines, from Comamonas testosteroni associated with a rhabditid entomopathogenic nematode against major human-pathogenic bacteria. Peptides. 2014 Mar;53:48-58.|[3]Zubare-Samuelov M, et al. Some sweet and bitter tastants stimulate inhibitory pathway of adenylyl cyclase via melatonin and alpha 2-adrenergic receptors in Xenopus laevis melanophores. Am J Physiol Cell Physiol. 2003 Nov;285 (5) :C1255-62.

Blue Ice

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

http://file.medchemexpress.com/batch_PDF/HY-P2092/Cyclo-L-leucyl-L-tryptophyl-SDS-MedChemExpress.pdf

Peptides

No Development Reported