Cyclomarinemonomeer-1

Cyclomarin monomer-1 (Compound 5), a cyclomarin monomer, is a pre-dimerization precursor that can form Homo-BacPROTACs targeting the degradation of ClpC1. Cyclomarin monomer-1 binds to the Mtb ClpC1 protein with a KD of 3.5 nM. The MIC of Cyclomarin monomer-1 against the Mtb H37Rv standard strain is 1.6 μM. Cyclomarin monomer-1 can be used as a key intermediate in the development of Homo-BacPROTACs[1].

12352209

Bacterial; Drug Intermediate

Anti-infection; Others

COVID-19-immunoregulation

Infection

C#CCN1C2=C(C(C[C@H](NC([C@H](C(C)C)NC([C@H](CC(C)C)N(C)C([C@@H](N3)C(C)C)=O)=O)=O)C(N([C@@H](C[C@H](CO)C)C(N[C@@H](C)C(N[C@H](C3=O)[C@@H](C4=CC=CC=C4)OC)=O)=O)C)=O)=C1)C=CC=C2

C51H72N8O9

941.17

[1]Junk L, et al. Homo-BacPROTAC-induced degradation of ClpC1 as a strategy against drug-resistant mycobacteria. Nat Commun. 2024 Mar 5;15 (1) :2005

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-P11497/

Peptides

No Development Reported