CYP1B1 (NM 000104) Humaan Recombinant Proteïne

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The enzyme encoded by this gene localizes to the endoplasmic reticulum and metabolizes procarcinogens such as polycyclic aromatic hydrocarbons and 17beta-estradiol. Mutations in this gene have been associated with primary congenital glaucoma; therefore it is thought that the enzyme also metabolizes a signaling molecule involved in eye development, possibly a steroid. [provided by RefSeq, Jul 2008]

Purified recombinant protein of Human cytochrome P450, family 1, subfamily B, polypeptide 1 (CYP1B1), Leu40-Ala305, with N-terminal His tag, expressed in E. coli, 50ug

ASGD6; CP1B; CYPIB1; GLC3A; P4501B1

1545

Q16678, Q53TK1

NM_000104

2p22.2

E. coli

N-His

Metabolism of xenobiotics by cytochrome P450, Tryptophan metabolism

Metabolism of xenobiotics by cytochrome P450, Tryptophan metabolism

>50 ug/mL as determined by microplate BCA method

> 80% as determined by SDS-PAGE and Coomassie blue staining

Liquid

50mM Tris, 8M Urea, pH8.0.

Druggable Genome, P450

30 kDa

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

CYP1B1

Human

NP_000095

https://www.ncbi.nlm.nih.gov/gene/1545

https://www.uniprot.org/uniprot/Q16678

https://www.ncbi.nlm.nih.gov/nuccore/NM_000104

https://www.ncbi.nlm.nih.gov/nuccore/NP_000095