CYP2C9 Antilichaam - C-terminaal gebied: Biotine (ARP41809_P050-Biotine)

Cytochrome P450, family 2, subfamily C, polypeptide 9

CPC9, CYP2C, CYP2C10, CYPIIC9, P450IIC9

1559

P11712

NP_000762

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit, Sheep

The immunogen is a synthetic peptide directed towards the C terminal region of human CYP2C9

CYP2C9 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by rifampin. The enzyme is known to metabolize many xenobiotics, including phenytoin, tolbutamide, ibuprofen and S-warfarin. Studies identifying individuals who are poor metabolizers of phenytoin and tolbutamide suggest that CYP2C9 gene is polymorphic.This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by rifampin. The enzyme is known to metabolize many xenobiotics, including phenytoin, tolbutamide, ibuprofen and S-warfarin. Studies identifying individuals who are poor metabolizers of phenytoin and tolbutamide suggest that this gene is polymorphic. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

POR; CYP2D6; STAMBP; STAT5A; RNF32; ECSIT; MAST1; CDC37; RAB3D

Biotin

Polyclonal Antibody

WB

Affinity Purified

There is BioGPS gene expression data showing that CYP2C9 is expressed in Jurkat

0.5 mg/ml

Cow: 85%; Dog: 83%; Guinea Pig: 75%; Horse: 83%; Human: 100%; Mouse: 83%; Pig: 83%; Rabbit: 77%; Rat: 83%; Sheep: 83%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

55kDa

Mohammed (er) Br. J. Pharmacol. (2008) In press

Wet Ice

490

CYP2C9

CYP2C9

Rabbit

Cytochrome P450 2C9

NM_000771

AGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVPPFYQLCFIPV