CYP3A4 Antilichaam - middengebied: HRP (ARP51348 P050-HRP)

Cytochrome P450, family 3, subfamily A, polypeptide 4

HLP, CP33, CP34, CYP3A, NF-25, VDDR3, CYP3A3, P450C3, CYPIIIA3, CYPIIIA4, P450PCN1

1576

P08684

NP_059488

Human, Rat, Cow, Dog, Guinea Pig, Rabbit, Sheep

The immunogen is a synthetic peptide directed towards the middle region of human CYP3A4

This gene, CYP3A4, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs which are are used today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4.

UBC; PRKCA; PRKACA; PGRMC1; POR; GK; CYB5A; STUB1; AMFR; UGT2B7

HRP: Horseradish Peroxidase

Polyclonal Antibody

WB

Affinity Purified

0.5 mg/ml

Cow: 79%; Dog: 79%; Guinea Pig: 86%; Human: 100%; Rabbit: 79%; Rat: 86%; Sheep: 79%

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

57kDa

Wet Ice

503

CYP3A4

CYP3A4

Rabbit

Cytochrome P450 3A4

NM_017460

KSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSI