Cypemycine

Cypemycin is a linaridin antibiotic that can inhibit cancer cell activity, inhibits P388 leukemia cells with IC50 of 1.3 μg/mL. Cypemycin can inhibit human tumor cells such as HeLa S3, HHCC-1, HCCS-M and Slex with IC50 of >25 μg/mL[1].

154277-21-1

12352005

Antibiotic; Bacterial

Anti-infection

Cancer; Infection

O=C(N[C@H](C(N[C@H](C(N/C=C\SC1)=O)C(C)C)=O)CC(C)C)[C@H]1NC([C@H]([C@H](C)CC)NC(/C(NC([C@H](CO)NC(CNC([C@H](CCC(N)=O)NC([C@H]([C@H](C)CC)NC([C@H](C(C)C)NC([C@H](CC2=CC=CC=C2)NC([C@H](CCC(N)=O)NC([C@H](C)NC([C@H](C(C)C)NC(/C(NC([C@H]3N(CCC3)C(/C(NC([C@H](C)NC([C@H]4N(CCC4)C(/C(NC([C@H](C)N(C)C)=O)=C\C)=O)=O)=O)=C\C)=O)=O)=C\C)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=C\C)=O)=O

C99H154N24O24S

2096.49

[1]Wei Ding, et al. Substrate specificity of the cypemycin decarboxylase CypD. Synth Syst Biotechnol. 2018 Sep 15;3 (3) :159-162.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-N5186/

Natural Products

No Development Reported