Cys-GE11

Cys-GE11 is a short peptide modified with cysteine. Cys-GE11 can be linked to PEG-P (TMC-DTC) through the N-terminus of cysteine to form a targeted polymer. Cys-GE11 can target cells with high EGFR expression (such as SMMC-7721 cells) . Cys-GE11 can significantly enhance drug enrichment at the tumor site and exhibit low toxicity[1].

1421680-54-7

12352209

EGFR

JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Cancer-Kinase/protease

Cancer

O=C(N[C@@H](CC1=CC=C(C=C1)O)C(N[C@@H](CC2=CNC=N2)C(N[C@@H](CC3=CNC4=CC=CC=C34)C(N[C@@H](CC5=CC=C(C=C5)O)C(NCC(N[C@@H](CC6=CC=C(C=C6)O)C(N[C@@H]([C@H](O)C)C(N7[C@@H](CCC7)C(N[C@@H](CCC(N)=O)C(N[C@@H](CC(N)=O)C(N[C@@H](C(C)C)C(N[C@@H]([C@@H](C)CC)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CS)N

C78H102N18O20S

1643.82

[1]Zhou C, et al. GE11 peptide-installed chimaeric polymersomes tailor-made for high-efficiency EGFR-targeted protein therapy of orthotopic hepatocellular carcinoma. Acta Biomater. 2020 Sep 1;113:512-521.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-P11308/

Peptides

No Development Reported