Cys-PKHB1 (TFA)

Cys-PKHB1 (Cys-txCD47) TFA is a peptide conjugated to PKHB1, a CD47 agonist peptide and a thrombospondin-1 peptide mimic with antitumor effects. PKHB1 induces mitochondrial alterations, ROS generation, intracellular Ca+ accumulation, and calcium-dependent cell death in breast cancer cells. PKHB1 induces immune system activation in breast cancer cells through immunogenic cell death[1][2].

Cys-txCD47 (TFA)

12352209

CD47; Reactive Oxygen Species (ROS) ; Thrombopoietin Receptor

Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Cancer; Inflammation/Immunology

99.43

NCCCC[C@H](C(O)=O)NC([C@H](CCCCN)NC([C@@H](NC([C@H](CCSC)NC([C@H](C(C)C)NC([C@H](C(C)C)NC([C@@H](NC([C@@H](NC([C@H](CCCNC(N)=N)NC([C@@H](CCCCN)NC([C@@H](N)CS)=O)=O)=O)CC1=CC=CC=C1)=O)CC2=CC=C(C=C2)O)=O)=O)=O)=O)CC3=CNC4=CC=CC=C34)=O)=O.OC(C(F)(F)F)=O.[x]

C71H110N18O13S2.xC2HF3O2

1487.88 (free base)

[1]Mohanty A, et al. Protein-Caged Nanoparticles: A Promising Nanomedicine Against Cancer. Chonnam Med J. 2023 Jan;59 (1) :1-12.|[2]Calvillo-Rodríguez KM, et al. PKHB1, a thrombospondin-1 peptide mimic, induces anti-tumor effect through immunogenic cell death induction in breast cancer cells. Oncoimmunology. 2022 Apr 4;11 (1) :2054305.

Blue Ice

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

http://file.medchemexpress.com/batch_PDF/HY-P11205A/Cys-PKHB1-TFA-SDS-MedChemExpress.pdf

Peptides

No Development Reported