Cytochroom P450 17A1 (CYP17A1) Muismonoklonale antilichamen [Kloon ID: LBI3F11]

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. It has both 17alpha-hydroxylase and 17,20-lyase activities and is a key enzyme in the steroidogenic pathway that produces progestins, mineralocorticoids, glucocorticoids, androgens, and estrogens. Mutations in this gene are associated with isolated steroid-17 alpha-hydroxylase deficiency, 17-alpha-hydroxylase/17,20-lyase deficiency, pseudohermaphroditism, and adrenal hyperplasia. [provided by RefSeq, Jul 2008]

Carrier-free (BSA/glycerol-free) CYP17A1 mouse monoclonal antibody, clone LBI3F11

CPT7; CYP17; P450C17; S17AH

Homo sapiens cytochrome P450 family 17 subfamily A member 1 (CYP17A1), mRNA.

1586

P05093

Unconjugated

C21-Steroid hormone metabolism, Metabolic pathways

C21-Steroid hormone metabolism, Metabolic pathways

WB 1:2000, IHC 1:150, FLOW 1:100

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Druggable Genome, P450

Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

CYP17A1

https://www.ncbi.nlm.nih.gov/gene/?term=1586

https://www.uniprot.org/uniprot/P05093