Cytokeratine 19 Antilichaam [SB39g]

Keratins are a family of intermediate filament proteins that assemble into filaments through forming heterodimers of one type I keratin (keratins 9 to 23) and one type II keratin (keratins 1-8) . The two keratin types share only 30% sequence homology. Keratins demonstrate tissue- and differentiation-specific expression profiles. Cytokeratin 19 is the smallest human keratin. It is found in many simple and some non-keratinizing stratified squamous epithelia and is often co-expressed with keratin 7. Cytokeratin 19 has been implicated as a marker for stem cells in some tissues such as hair follicles in the skin. Monoclonal antibodies to cytokeratin proteins can be useful markers for tumor identification and classification. The degree of cytokeratin 19 positivity in breast cancer distinguishes malignant from benign tumors. Cytokeratin 19 is also associated with malignant transformation in esophageal and pancreatic cancers.

3880

P08727

P08727

Human

Recombinant C-terminal cytokeratin 19

[SB39g]

Unconjugated

Primary Antibodies

Signal Transduction

0.1 mg/mL

Supplied in borate buffered saline, pH 8.2; No preservatives or amine-containing buffer salts added

None

Blue Ice

Store vial at 2-8˚ C

IgG2a

Cytokeratin 19

Cytokeratin 19 Antibody [SB39g] for use in flow cytometry, immunocytochemistry, ELISA, western blotting, and immunoprecipitation assays.

KRT19

Keratin, type I cytoskeletal 19

Homo sapiens

CK 19, keratin 19

IHC-Fr, Flow

Liquid