Cytokeratine-antilichaam [7H8C4]

Biochemically, most members of the CK family fall into one of two classes, type I (acidic polypeptides) and type II (basic polypeptides) . The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. Cytokeratins comprise a diverse group of intermediate filament proteins (IFPs) that are expressed as pairs in both keratinized and non-keratinized epithelial tissue. Cytokeratins play a critical role in differentiation and tissue specialization and function to maintain the overall structural integrity of epithelial cells. Cytokeratins have been found to be useful markers of tissue differentiation which is directly applicable to the characterization of malignant tumors.

3852

P13647

P13647

Human

Ni-NTA purified truncated recombinant CK expressed in E. Coli strain BL21 (DE3) .

7H8C4

Unconjugated

Primary Antibodies

Other

Batch dependent

Ascitic fluid containing 0.03% sodium azide.

None

Blue Ice

Cytokeratin (Pan) monoclonal antibody can be stored at -20˚ C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG1

KRT5

Keratin 5

Homo sapiens

Scope A. Schwendenwein I. Frommlet F. Vet Rec. 2006, Dec 16, 159 (25) : 839-43.

Somjen D. Katzburg S. Posner GH. et al. J Cell Biochem. 2007, Apr 15, 100 (6) : 1406-14.

58 kDa cytokeratin, CK-5, K5, CK5, DDD, DDD1, EBS2, KRT5A

ELISA, WB, IHC

143811411