Cytokeratine5 Antilichaam [3E2F1]

CK5 (keratin 5) is a member of the keratin gene family. Biochemically, most members of the CK family fall into one of two classes, type I (acidic polypeptides) and type II (basic polypeptides) . The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the basal layer of the epidermis with family member KRT14. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. At least one member of the acidic family and one member of the basic family is expressed in all epithelial cells. Cytokeratin 5 is expressed in normal basal cells. Mutations of the Cytokeratin5 gene (KRT5) have been shown to result in the autosomal dominant disorderepidermolysis bullosa (EB) . Defects in KRT5 are a cause of epidermolysis bullosa simplex.

3852

P13647

P13647

Human

Ni-NTA purified truncated recombinant CK5-Trx-His expressed in E. Coli strain BL21 (DE3) .

3E2F1

Unconjugated

Primary Antibodies

Other

Batch dependent

Ascitic fluid containing 0.03% sodium azide.

None

Blue Ice

Cytokeratin 5 monoclonal antibody can be stored at -20˚ C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG1

KRT5

Keratin 5

Homo sapiens

Canedo-Patzi AM. Leon-Bojorge B. de Ortiz-Hidalgo C. Gac Med Mex. 2006, Jan-Feb, 142 (1) :59-66. Spanish.

Leibl S. Moinfar F. Am J Surg Pathol. 2006, Apr, 30 (4) :450-6.

58 kDa cytokeratin, CK-5, K5, CK5, DDD, DDD1, EBS2, KRT5A

ELISA, WB, IHC

143811411