[D-Arg1, D-Trp5,7,9, Leu11]-Substance P

[D-Arg1, D-Trp5, 7, 9, Leu11]-Substance P is a potent inhibitor of cell growth in small cell lung cancer (SCLC) . [D-Arg1, D-Trp5, 7, 9, Leu11]-Substance P is also a neuropeptide antagonist, capable of blocking colony formation stimulated by various neuropeptides (including vasopressin and bradykinin) . [D-Arg1, D-Trp5, 7, 9, Leu11]-Substance P inhibits the mobilization of Ca2+ and the activation of mitogen-activated protein kinases induced by vasopressin or bradykinin. [D-Arg1, D-Trp5, 7, 9, Leu11]-Substance P inhibits the growth of H-69 xenograft tumors in nude mice[1].

122481-75-8

12352209

Neurotensin Receptor

GPCR/G Protein; Neuronal Signaling

Cancer-Kinase/protease

Cancer; Neurological Disease

O=C(N1[C@@H](CCC1)C(N[C@@H](CCCCN)C(N2[C@@H](CCC2)C(N[C@H](CC3=CNC4=CC=CC=C34)C(N[C@@H](CCC(N)=O)C(N[C@H](CC5=CNC6=CC=CC=C56)C(N[C@@H](CC7=CC=CC=C7)C(N[C@H](CC8=CNC9=CC=CC=C89)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@@H](CCCNC(N)=N)N

C81H110N20O12

1555.87

[1]Seckl MJ, et al. [D-Arg1, D-Trp5,7,9, Leu11]substance P: a novel potent inhibitor of signal transduction and growth in vitro and in vivo in small cell lung cancer cells. Cancer Res. 1997 Jan 1;57 (1) :51-4.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-P11405/

Peptides

No Development Reported