[D-Cys6, Asn7, D-Ala11, Cys14]-Bombesin (6-14)

[D-Cys6, Asn7, D-Ala11, Cys14]-Bombesin (6-14), a synthetic peptide, is a non-selective bombesin receptor agonist. [D-Cys6, Asn7, D-Ala11, Cys14]-Bombesin (6-14) has preferred pEC50 values of 8.06 for the neurotrophin B bombesin receptor (BB1), 8.69 for the gastrin-releasing peptide bombesin receptor (BB2), and 6.71 for the orphan receptor (BB3) . [D-Cys6, Asn7, D-Ala11, Cys14]-Bombesin (6-14) can be used to study diseases related to bombesin receptors, such as cancer and neurological disorders[1].

349657-39-2

12352209

Bombesin Receptor

GPCR/G Protein

Cancer; Neurological Disease

O=C([C@@H](NC([C@@H](CSSC[C@H](NC([C@@H](NC([C@@H](NC([C@H](NC([C@@H](NC([C@@H](NC1=O)C)=O)C(C)C)=O)C)=O)CC2=CN=CN2)=O)CC(C)C)=O)C(N)=O)N)=O)CC(N)=O)N[C@H]1CC3=CNC4=CC=CC=C34

C44H64N14O10S2

1013.20

[1]Darker JG, et al. Discovery of potent and selective peptide agonists at the GRP-preferring bombesin receptor (BB2) . J Pept Sci. 2001 Nov;7 (11) :598-605.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-P11408/

Peptides

No Development Reported